3-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine → HCID 66707312, compound

HRID 2041414Notes

Reaction equation

HRID 2041414 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.BrC[CH2:28][CH2:29][C:30]1[O:34][N:33]=[C:32]([C:35]([CH3:38])([CH3:37])[CH3:36])[N:31]=1>>[ClH:19].[C:35]([C:32]1[N:31]=[C:30]([CH2:29][CH2:28][CH2:21][S:20][C:15]2[C:12]3[CH2:13][CH2:14][NH:8][CH2:9][CH2:10][C:11]=3[CH:18]=[CH:17][C:16]=2[Cl:19])[O:34][N:33]=1)([CH3:38])([CH3:37])[CH3:36]

Participants

3

Reactant 2

HCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 57656053HCID 57656053, compound

Product 1

HCID 66707312HCID 66707312, compound

Procedure

Use a method similar to the Example 387, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 5-(3-bromopropyl)-3-tert-butyl-[1,2,4]oxadiazole to give, after deprotection using a method similar to the General Procedure 1-4, the title compound as a white solid. MS (APCI+) m/z 380 (M+H)+.

Workup

  1. customto give

Sources & evidence

ORD record
ord-6db5460050ca479cb9979a2fb8fb46ec
Source dataset
uspto-grants-2013_11
Patent number
US08580780B2

Reaction notes

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