HCID 55138441, compound → HCID 57656007, compound

Participants

Reaction Steps

Heat 2-(3-bromo-phenylthio)-1-phenyl-ethanone (4 g, 13 mmol) in polyphosphoric acid (4g) at 80° C. for 4 h. Add EtOAc and water to the mixture and wash with saturated aqueous NaHCO3 and brine. Dry the organic layer over Na2SO4, filter and concentrate in vacuo. Slurry the residue in hexane and purify by chromatography on silica gel eluting with hexane to give the desired intermediate that is used without further purification (2.7 g, 72%). MS (GCMS) m/z: 289 M+.

Provenance & Evidence