HCID 57655962, compound → HCID 57656379, compound

Participants

Reaction Conditions

Reaction Steps

Add manganese dioxide (1.132 g, 13 mmol) to a solution of N-(tert-butoxycarbonyl)-3-fluoro-4-(1-hydroxy-3,3-dimethyl-butyl)-benzylamine (283 mg, 0.87 mmol) in anhydrous 1,4-dioxane (11.5 mL) at room temperature. Heat the reaction mixture at 70° C. overnight. Filter the reaction mixture over Celite® and concentrate in vacuo. Purify by chromatography on silica gel eluting with hexane/EtOAc (4:1) to obtain the desired intermediate as an oil (216 mg, 77%).

Provenance & Evidence