HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Aminomethyl-2-(1-hydroxy-3-methyl-butyl)-pyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-Azidomethyl-2-(3-methyl-butyryl)-pyridine | HCID 57656340 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Aminomethyl-2-(1-hydroxy-3-methyl-butyl)-pyridine hydrochloride | HCID 66706953 | 98% |
Reaction Steps
Add 10% Pd/C (20 mg) to a solution of 5-azidomethyl-2-(3-methyl-butyryl)-pyridine (80 mg, 0.367 mmol) in ethanol (10 mL) containing concentrated HCl (1 mL). Submit the mixture to hydrogenation at atmospheric pressure for 2 h. Filter the reaction mixture over Celite® and concentrate in vacuo to afford the desired intermediate (95 mg, 98%). MS (ES+) m/z: 195 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-4615701a557e44579771e21e6e5c570b |
| Source note | uspto-grants-2013_11 |