HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2041575Generated: November 2, 2026
2-(tert-Butyldimethylsilyloxymethyl)-5-(1-hydroxy-3-methyl-butyl)-pyridine → 2-(tert-Butyldimethylsilyloxymethyl)-5-(3-methyl-butyryl)-pyridine
https://huagongshe.com/reaction/2041575
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(tert-Butyldimethylsilyloxymethyl)-5-(1-hydroxy-3-methyl-butyl)-pyridine | HCID 57656529 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(tert-Butyldimethylsilyloxymethyl)-5-(3-methyl-butyryl)-pyridine | HCID 57656164 | 100% |
Reaction Steps
Add manganese dioxide (1.32 g) to a stirred solution of 2-(tert-butyldimethylsilyloxymethyl)-5-(1-hydroxy-3-methyl-butyl)-pyridine (330 mg, 1.066 mmol) in anhydrous 1,4-dioxane (30 mL). Heat the mixture to 70° C. overnight. Cool the reaction mixture to room temperature, filter through Celite® and wash with EtOAc. Concentrate the filtrate in vacuo to provide the desired intermediate as oil (327 mg, 100%). GC-MS m/z: 307 (M+.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08580780B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-7fe06885d9b84d9b93af96cca6611874 |
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| Source note | uspto-grants-2013_11 |
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