HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2041580Generated: November 2, 2026
Triethylamine → 5-Methanesulfonyloxymethyl-2-(3-methyl-butyryl)-pyridine
https://huagongshe.com/reaction/2041580
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 5-Hydroxymethyl-2-(3-methyl-butyryl)-pyridine | HCID 57656192 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Methanesulfonyloxymethyl-2-(3-methyl-butyryl)-pyridine | HCID 57656345 | 87% |
Reaction Steps
Dissolve 5-hydroxymethyl-2-(3-methyl-butyryl)-pyridine (210 mg, 1.086 mmol) in dichloromethane (5 mL). Cool to 0° C. and add triethylamine (0.167 mL, 1.195 mmol) and methanesulfonyl chloride (0.093 mL, 1.195 mmol). Allow the mixture to warm to room temperature and stir for 2 h. Dilute the reaction mixture with dichloromethane and wash with saturated aqueous NaHCO3. Dry the organic phase over Na2SO4, filter and concentrate in vacuo to provide the title compound (256 mg, 87%). GC-MS m/z: 271
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08580780B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-cf4d8b0aa1d94ecf80b5f64b8fc2c2b7 |
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| Source note | uspto-grants-2013_11 |
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