HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoro-2-(2-pyridyl)ethyl trifluoromethanesulfonate → 7-Chloro-6-(2,2-difluoro-2-pyridin-2-yl-ethylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoro-2-(2-pyridyl)ethyl trifluoromethanesulfonate | HCID 11066224 | — |
| Reactant | 3-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 57655979 | — |
| Product | 7-Chloro-6-(2,2-difluoro-2-pyridin-2-yl-ethylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine Hydrochloride | HCID 66707183 | 66% |
Reaction Steps
Example 647 may be prepared essentially as described in Example 646 using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 2,2-difluoro-2-pyridin-2-yl-ethyl trifluoromethanesulfonate (prepared by following the procedure described in J. Med. Chem. 2003, 46, 461-473) (66% yield, MS (ES+) m/z 355 (M+H)+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c60a5f231a9b4f88a9cdc38c9a31426b |
| Source note | uspto-grants-2013_11 |