Hydrochloric Acid → HCID 68161466, compound

Participants

Reaction Steps

A solution of 1,1-dimethylethyl[1-acetyl-2-methyl-6-(4-methyl-1H-imidazol-1-yl)-1,2,3,4-tetrahydro-4-quinolinyl]carbamate (for a preparation see Intermediate 62) (5.7 g, 14.83 mmol) in dichloromethane (DCM) (40 mL) was treated at room temperature with HCl (4N in 1,4-dioxane, 20 ml, 80 mmol). An ice bath was used during the addition to keep the temperature below 30° C. Once the addition was completed, DCM (20 mL) was added and the resulting mixture was stirred at room temperature for 2 h then concentrated in vacuo to give (cis)-1-acetyl-2-methyl-6-(4-methyl-1H-imidazol-1-yl)-1,2,3,4-tetrahydro-4-quinolinamine di-hydrochloride as (5.12 g, 14.33 mmol, 97%) as a white solid.

Provenance & Evidence