Trifluoroacetic acid → HCID 68161452, compound

Participants

Reaction Steps

A solution of 1,1-dimethylethyl (2-{4-[(2S,4R)-1-acetyl-2-methyl-4-(2-pyridinylamino)-1,2,3,4-tetrahydro-6-quinolinyl]-1H-pyrazol-1-yl}ethyl)methylcarbamate (for a preparation see intermediate 60) (126 mg, 0.250 mmol) in dichloromethane (DCM) (2 mL) was treated at room temperature with trifluoroacetic acid (TFA) (500 μl, 6.49 mmol) and the resulting mixture was stirred at this temperature for 1.5 h then concentrated in vacuo. The residue was dissolved in MeOH (1 mL) and purified by MDAP (modifier: formic acid). The desired fractions were combined and the solvent was removed under vacuo to give (2S,4R)-1-acetyl-2-methyl-6-{1-[2-(methylamino)ethyl]-1H-pyrazol-4-yl}-N-2-pyridinyl-1,2,3,4-tetrahydro-4-quinolinamine formate (93 mg, 0.206 mmol, 83% yield) as a cream solid.

Provenance & Evidence