Diisopropylethylamine → HCID 67205432, compound

Participants

Reaction Steps

A solution of 1-acetyl-2-methyl-6-(4-methyl-1H-imidazol-1-yl)-1,2,3,4-tetrahydro-4-quinolinamine di-hydrochloride (for a preparation see intermediate 61) (85 mg, 0.299 mmol) in NMP (2 mL) was treated with DIPEA (0.209 ml, 1.196 mmol), then 6-chloro-3-pyridinecarbonitrile (49.7 mg, 0.359 mmol) and the resulting mixture was heated at 200° C. for 30 min under microwave irradiation, then cooled to room temperature and the solution purified by MDAP to give 6-{[1-acetyl-2-methyl-6-(4-methyl-1H-imidazol-1-yl)-1,2,3,4-tetrahydro-4-quinolinyl]amino}-3-pyridinecarbonitrile (12.2 mg, 0.032 mmol, 11% yield) as a beige solid.

Provenance & Evidence