HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-Bromonicotinoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Bromonicotinic acid | HCID 88707 | — |
| Product | 5-Bromonicotinoyl chloride | HCID 2781223 | — |
Reaction Steps
To a mixture of 5-bromonicotinic acid (10 g) in thionyl chloride (25 mL) was added anhydrous dimethylformamide (DMF) (0.5 mL). The whole was heated to reflux for overnight. After cooling to RT, the excess thionyl chloride was removed under reduced pressure. A white solid (3) (11 g) was obtained, which was used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08585926B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-34b76b4d9aec4116a60692cb33427d3c |
| Source note | uspto-grants-2013_11 |