HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Biphenyl, 3,5-diisopropyl-4-amino-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 4-Bromo-2,6-diisopropylaniline | HCID 11780114 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Water | HCID 962 | — |
| Product | Biphenyl, 3,5-diisopropyl-4-amino- | HCID 3025997 | 57% |
Reaction Steps
4-bromo-2,6-diisopropylaniline (16 g, 62.5 mmol), (PPh3)4Pd (2.2 g, 1.9 mmol), phenylboronic acid (11 g, 87.5 mmol), K3PO4 (26 g, 187 mmol), 400 mL of toluene and 40 mL of water were charged and heated up to reflux for overnight. The reaction mixture was purified by column and distillation method to give 9 g liquid (57% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586204B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-1ed70af69d13430eaafb7c9b3d16fade |
| Source note | uspto-grants-2013_11 |