Tetrahydrofuran → HCID 69673986, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, 78 ml of tetrahydrofuran, 5.49 g of 4-bromothiazole, and 20.3 ml of triethylamine were added to 1184 mg of dichlorobis(triphenylphosphine)palladium, 322 mg of copper iodide, and 6.64 g of N-(3-butynyl)phthalimide. The obtained mixture was stirred under reflux for 5 hours. After completion of the stirring, the reaction solution was cooled to a room temperature, and a solid was then filtrated. The filtrate was concentrated, and the residue was then purified by column chromatography (Wako Gel C-200; toluene:ethyl acetate=4:1), so as to obtain 6.35 g of a phthalimide compound.

Provenance & Evidence