Dimethylformamide → HCID 69673423, compound

Participants

Reaction Conditions

Reaction Steps

550 mg of 2-vinyl-4-phenyl-3-butynylamine, 500 mg of 4-chloroquinazoline, and 636 μl of triethylamine were added to 15 ml of DMF, and the obtained mixture was then stirred at 80° C. for 5 hours. Thereafter, the reaction solution was cooled, and 20 ml of water was then added thereto, followed by extraction with 50 ml of ethyl acetate twice. The organic layer was washed with 50 ml of a saturated brine twice, and it was then dried over sodium sulfate. The sodium sulfate was filtrated, and the organic layer was then concentrated. The residue was purified using an automated flash chromatography instrument (manufactured by Biotage AB; Isolera™), so as to obtain 750 mg of a product of interest.

Provenance & Evidence