1,3-Dichloroacetone → HCID 66994993, compound

Temperature

-78 °C

To a solution of 1-bromo-3-chloro-2-fluorobenzene (1.4 g, 6.7 mmol) in dry diethyl ether (25 mL), at −78° C. under nitrogen was added n-hexyllithium (2.5 M in hexane, 3.2 ml, 8.0 mmol) dropwise. The mixture was stirred for 10 min after which a solution of 1,3-dichloroacetone (1.1 g, 7.3 mmol) in dry diethyl ether (10 ml) was added dropwise. The resulting mixture was stirred at −78° C. for 0.5 h and then brought to ambient temperature and stirred for 2 h. Aqueous saturated ammonium chloride (25 ml) was added and the mixture was extracted with ethylacetate (3×25 ml). The combined organic phase was dried (Na2SO4), filtered and evaporated to dryness. The crude product was purified by flash column chromatography on silica gel (ethylacetate/isooctane, 1:9 to 1:1) to give the title compound (0.88 g, 51%). MS m/z (rel. intensity, 70 eV) 257 (M+, 1), 209 (64), 207 (bp), 143 (44), 77 (13).

1. additionwas added dropwise
2. custombrought to ambient temperature
3. stirringstirred for 2 h
4. extractionthe mixture was extracted with ethylacetate (3×25 ml)
5. dry with materialThe combined organic phase was dried (Na2SO4)
6. filtrationfiltered
7. customevaporated to dryness
8. customThe crude product was purified by flash column chromatography on silica gel (ethylacetate/isooctane, 1:9 to 1:1)

ORD record

ord-024a81c9abf649cfb00521fc1deebed3

Source dataset

uspto-grants-2013_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08586572B2