3-(Trifluoromethyl)phenyl isocyanate → HCID 44221513, compound

HRID 2041913Notes

Reaction equation

HRID 2041913 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[CH3:9])[NH2:5].[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[C:14]([N:18]=[C:19]=[O:20])[CH:15]=[CH:16][CH:17]=1>>[I:1][C:2]1[CH:3]=[C:4]([NH:5][C:19]([NH:18][C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([C:11]([F:10])([F:21])[F:22])[CH:13]=2)=[O:20])[CH:6]=[CH:7][C:8]=1[CH3:9]

Participants

3

Reactant 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 1188893-Iodo-p-toluidine

Product 1

HCID 44221513HCID 44221513, compound

Procedure

A mixture of 3-iodo-4-methylaniline (1.17 g, 5 mmol) and 3-(trifluoromethyl)-phenylisocyanate (1.03 g, 5.5 mmol) was stirred at rt for 4 h. Filtration (ethyl acetate wash) yielded the desired product.

Workup

  1. filtrationFiltration (ethyl acetate wash)

Sources & evidence

ORD record
ord-5bb2200f7e60447b811ff58133b8b246
Source dataset
uspto-grants-2013_11
Patent number
US08586566B2

Reaction notes

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