HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid → N-[6-(3-Hydroxyazetidin-1-yl)pyridin-3-yl]-5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid | HCID 57431513 | — |
| Reactant | 1-(5-Aminopyridin-2-yl)azetidin-3-ol | HCID 57431525 | — |
| Product | N-[6-(3-Hydroxyazetidin-1-yl)pyridin-3-yl]-5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxamide | HCID 57431524 | — |
Reaction Steps
The process is carried out according to the method described in example 2, using 0.5 g (1.74 mmol) of 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid (example 1.1) and 0.35 g (2.09 mmol) of 2-(3-hydroxyazetidin-1-yl)-5-aminopyridine, obtained in step 10.2 (Compound Ve).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586573B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-320096c8d5934cf99de11bdee57e6ec2 |
| Source note | uspto-grants-2013_11 |