HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 57431528, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | HCID 57431527 | HCID 57431527 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 57431528 | HCID 57431528 | — |
Reaction Steps
A solution of 1 g (3.02 mmol) of 6-(pyrrolidin-1-yl)-4-trifluoromethyl-3-(tert-butoxycarbonylamino)pyridine, prepared in step 11.3, in 11 ml of 4N hydrochloric acid in dioxane is stirred for 5 hours at reflux. 200 ml of ethyl ether are subsequently added to the cooled reaction mixture. 0.8 g of a precipitate is recovered by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586573B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-25583ef00ea64156aa08b98ce7950468 |
| Source note | uspto-grants-2013_11 |