HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Aminopyridin-2-yl)azetidin-3-ol → N-[6-(3-Hydroxyazetidin-1-yl)pyridin-3-yl]-1-(3-fluorobenzyl)-5-trifluoromethyl-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Aminopyridin-2-yl)azetidin-3-ol | HCID 57431525 | — |
| Reactant | 5-trifluoromethyl-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid | HCID 57431532 | — |
| Product | N-[6-(3-Hydroxyazetidin-1-yl)pyridin-3-yl]-1-(3-fluorobenzyl)-5-trifluoromethyl-1H-indole-2-carboxamide | HCID 57431500 | — |
Reaction Steps
The process is carried out according to the method described in example 2, using 5-trifluoromethyl-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid (WO 2006/072736) and 2-(3-hydroxyazetidin-1-yl)-5-aminopyridine, prepared in step 10.2 of example 10 (Compound Ve).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586573B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-9c4d905f22ae43b7967c9504395029ca |
| Source note | uspto-grants-2013_11 |