HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Aminopyridin-2-yl)azetidin-3-ol → N-[6-(3-Hydroxyazetidin-1-yl)pyridin-3-yl]-1-(3-fluorobenzyl)-6-trifluoromethyl-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Aminopyridin-2-yl)azetidin-3-ol | HCID 57431525 | — |
| Reactant | 6-trifluoromethyl-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid | HCID 57431533 | — |
| Product | N-[6-(3-Hydroxyazetidin-1-yl)pyridin-3-yl]-1-(3-fluorobenzyl)-6-trifluoromethyl-1H-indole-2-carboxamide | HCID 57431501 | — |
Reaction Steps
The process is carried out according to the method described in example 2, using 6-trifluoromethyl-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid and 2-(3-hydroxyazetidin-1-yl)-5-aminopyridine, prepared in step 10.2 of example 10 (Compound Ve).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586573B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-742a07bb2f5749ffb506163b6f2ed1bb |
| Source note | uspto-grants-2013_11 |