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Triethylamine → (3-(2-Tert-butylphenoxy)azetidin-1-yl)(5-methylisoxazol-3-yl)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-Methylisoxazole-3-carbonyl chloride | HCID 2736894 | — |
| 反応物 | 3-(2-Tert-butylphenoxy)azetidine | HCID 53409530 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (3-(2-Tert-butylphenoxy)azetidin-1-yl)(5-methylisoxazol-3-yl)methanone | HCID 59577162 | 83.5% |
反応手順
To a stirred solution of 3-(2-tert-butylphenoxy)azetidine (0.18 g, 0.80 mmol) and triethylamine (0.24 g, 2.4 mmol) in methylene chloride (4.0 mL) was added 5-methylisoxazole-3-carbonyl chloride (0.12 g, 0.80 mmol) at room temperature. After 2 h the reaction mixture was directly purified by flash column chromatography (silica gel, 80:20 heptane/ethyl acetate) to provide (3-(2-tert-butylphenoxy)azetidin-1-yl)(5-methylisoxazol-3-yl)methanone (0.21 g, 83%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08586571B2 |
| 出典データセット | uspto-grants-2013_11 |
| ORD ID | ord-0171da3054464bd58bc8649caf102b85 |
| 出典メモ | uspto-grants-2013_11 |