Benzyl Alcohol → 1-(Benzyloxy)-2,3-difluoro-4-nitrobenzene

Participants

Reaction Steps

A solution of 1,2,3-trifluoro-4-nitro-benzene (30 g, 0.17 mol) and benzyl alcohol (18.4 g, 0.17 mol) in DMF (300 mL) was treated with K2CO3 (35 g, 0.25 mol) and the resulting mixture was stirred at RT for 8 h. Water (300 mL) was added, and the mixture was extracted with EtOAc (3×500 mL). The combined organics were washed with brine, dried (MgSO4), concentrated in vacuo and chromatographed on silica gel to give 1-benzyloxy-2,3-difluoro-4-nitrobenzene (16 g, 36% yield). 1H NMR (400 MHz, DMSO-d6): δ 8.06 (m, 1H), 7.49-7.30 (m, 6H), 5.37 (s, 2H).

Provenance & Evidence