Trichloroethanol → HCID 67253960, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of 1-(2-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-tert-butyl-1H-pyrazole-5-carboxylic acid from Example B1 (0.320 g, 0.738 mmol, 1.0 eq) and TEA (0.118 ml, 0.849 mmol, 1.15 eq) in 1,4-dioxane (7.5 ml) at 20° C. was added DPPA (0.183 ml, 0.849 mmol, 1.15 eq). After 30 min, 2,2,2-trichloroethanol (1.0 ml, 10.4 mmol, 14 eq) was added and the reaction was stirred with heating at 100° C. After 4 h, the completed reaction was diluted with brine and extracted with EtOAc (2×). The combined organics were washed with 5% citric acid (1×), satd. NaHCO3 (1×) and brine (1×), dried (MgSO4), concentrated in vacuo and purified by silica gel chromatography to afford benzyl 6-(3-tert-butyl-5-((2,2,2-trichloroethoxy)carbonyl)amino-1H-pyrazol-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (0.260 g, 61% yield) as an oil. MS (ESI) m/z: 579.0 (M+H+), 581.0 (M+2+H+).

Provenance & Evidence