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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2042139Generated: November 4, 2026

1-Ethynyl-4-fluorobenzene → 6-(4-Fluoro-phenylethynyl)-2-methyl-pyrazolo[1,5-a]pyrimidine

https://huagongshe.com/reaction/2042139

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethynyl-4-fluorobenzeneHCID 522627—
Reactant6-Bromo-2-methylpyrazolo[1,5-a]pyrimidineHCID 15980041—
Product6-(4-Fluoro-phenylethynyl)-2-methyl-pyrazolo[1,5-a]pyrimidineHCID 53247075—

Reaction Steps

The title compound, light yellow solid, MS: m/e=252.1 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-methylpyrazolo[1,5-a]pyrimidine and 1-ethynyl-4-fluoro-benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08586581B2
Source datasetuspto-grants-2013_11
ORD IDord-d2f5e52874304fb88b576b1897cf787c
Source noteuspto-grants-2013_11