p-Ethynyltoluene → 2-Methyl-6-p-tolylethynyl-pyrazolo[1,5-a]pyrimidine

HRID 2042141Notes

Reaction equation

Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([CH3:11])[CH:10]=2)[CH:7]=1.[C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)#[CH:13]>>[CH3:11][C:9]1[CH:10]=[C:5]2[N:4]=[CH:3][C:2]([C:13]#[C:12][C:14]3[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=3)=[CH:7][N:6]2[N:8]=1

Participants

Reactant 2

HCID 13018p-Ethynyltoluene

HCID 159800416-Bromo-2-methylpyrazolo[1,5-a]pyrimidine

Product 1

HCID 532470772-Methyl-6-p-tolylethynyl-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, brown solid, MS: m/e=248.2 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-methylpyrazolo[1,5-a]pyrimidine and 4-ethynyltoluene.

Sources & evidence

ORD record: ord-58f06026c7684f68b23abb42b9667c7c
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08586581B2

Reaction notes

Loading…