Benzene, 1-chloro-4-ethynyl- → 6-(4-Chloro-phenylethynyl)-2-methyl-pyrazolo[1,5-a]pyrimidine

HRID 2042142Notes

Reaction equation

HRID 2042142 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([CH3:11])[CH:10]=2)[CH:7]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]#[CH:20])=[CH:15][CH:14]=1>>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]#[C:20][C:2]2[CH:3]=[N:4][C:5]3[N:6]([N:8]=[C:9]([CH3:11])[CH:10]=3)[CH:7]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 70118Benzene, 1-chloro-4-ethynyl-HCID 159800416-Bromo-2-methylpyrazolo[1,5-a]pyrimidine

Product 1

HCID 532470786-(4-Chloro-phenylethynyl)-2-methyl-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, brown solid, MS: m/e=268.1 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-methylpyrazolo[1,5-a]pyrimidine and 1-chloro-4-ethynylbenzene.

Sources & evidence

ORD record
ord-c7df531b2f114fb79f747feaa93e0151
Source dataset
uspto-grants-2013_11
Patent number
US08586581B2

Reaction notes

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