2-Bromopropanedial → Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate

HRID 2042166Notes

Reaction equation

[NH2:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([O:9][CH3:10])=[O:8])[CH:3]=1.[Br:11][CH:12]([CH:15]=O)[CH:13]=O>>[CH3:10][O:9][C:7]([C:4]1[CH:3]=[C:2]2[N:1]=[CH:13][C:12]([Br:11])=[CH:15][N:6]2[N:5]=1)=[O:8]

Participants

Reactant 2

HCID 749452-Bromopropanedial

HCID 178498460HCID 178498460, compound

Product 1

HCID 49757483Methyl 6-bromopyrazolo[1,5-a]pyrimidine-2-carboxylate

Procedure

The title compound, brown solid, MS: m/e=256.0/254.1 (M+H+), can be prepared in accordance with the general method of example 9, step 1 from methyl 5-amino-1H-pyrazole-3-carboxylate and 2-bromomalonaldehyde.

Sources & evidence

ORD record: ord-fe4ee37803344eb19a2fd99a41c8b698
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08586581B2

Reaction notes

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