HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2042183Generated: November 1, 2026
Oxalyl chloride → 2,2-Dimethyl-3-acetyloxypropionyl chloride
https://huagongshe.com/reaction/2042183
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-(Acetyloxy)-2,2-dimethylpropanoic acid | HCID 13192621 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,2-Dimethyl-3-acetyloxypropionyl chloride | HCID 11194663 | — |
Reaction Steps
To a solution of acetoxy-2,2-dimethyl-propionic acid (example 40, step 1) (2.2 g, 13.75 mmol) in CH2Cl2 (25 ml), were added oxalyl chloride (2.62 ml, 27.50 mmol) and 2-4 drops of DMF and stirred at 25° C. for 3 hours. The solvent was evaporated and the resulting acetic acid 2-chlorocarbonyl-2-methyl-propyl ester (2.4 g) was used directly in next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08586581B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-47d8682c2d9b41748a5777f1be30610b |
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| Source note | uspto-grants-2013_11 |
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