3-Chloro-5-iodo-pyridine → 2-tert-Butyl-6-(5-chloro-pyridin-3-ylethynyl)-[1,2,4]triazolo[1,5-a]pyrimidine

HRID 2042196Notes

Reaction equation

HRID 2042196 reaction equation
[C:1]([C:5]1[N:19]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][Si](C)(C)C)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:20][C:21]1[CH:22]=[N:23][CH:24]=[C:25](I)[CH:26]=1>>[C:1]([C:5]1[N:19]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][C:25]3[CH:24]=[N:23][CH:22]=[C:21]([Cl:20])[CH:26]=3)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 242291783-Chloro-5-iodo-pyridineHCID 583166982-tert-Butyl-6-trimethylsilanylethynyl-[1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 532475752-tert-Butyl-6-(5-chloro-pyridin-3-ylethynyl)-[1,2,4]triazolo[1,5-a]pyrimidine

Procedure

The title compound, a light yellow solid, MS: m/e=312.2/314.1 (M+H+), can be prepared in accordance with the general method of example 43, step 2 from 2-tert-butyl-6-trimethylsilanylethynyl-[1,2,4]triazolo[1,5-a]pyrimidine (example 43, step 1) and 3-chloro-5-iodopyridine.

Sources & evidence

ORD record
ord-678bc7237cbb4b72bdff3a3479b5df47
Source dataset
uspto-grants-2013_11
Patent number
US08586581B2

Reaction notes

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