Bromine → 7-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dione

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution in which thieno[3,2-d]pyrimidin-2,4(1H,3H)-dione (5.0 g, 29.5 mmol) was dissolved in glacial acetic acid (200 mL), bromine (4.55 mL, 89.0 mmol) was added. The reaction mixture solution was stirred at 110° C. for 30 hours, cooled to room temperature, and then slowly added to ice water (400 mL). Drying of thus prepared solid followed by filtration, washing several times with water and drying yielded the target compound 7-bromothieno[3,2-d]pyrimidin-2,4(1H,3H)-dione (6.5 g, 90% yield).

Herkunft & Nachweise