反应详情

1-Ethyl-4-(5-nitropyridin-2-yl)piperazine (3.09 g, 13.8 mmol) was dissolved in methanol (69 mL) and 10% Pd/C (300 mg) was added. The reaction mixture was stirred at room temperature for a day under a pressure of a balloon filled with hydrogen gas. The reaction mixture solution was concentrated by filtering with celite. The resultant target compound (2.4 g, 89% yield) was used in the following reaction without purification.

1. concentrationThe reaction mixture solution was concentrated
2. filtrationby filtering with celite