3-Aminophenylboronic acid → 7-(3-Aminophenyl)thieno[3,2-d]pyrimidin-2-amine

HRID 2042214Notes

Reaction equation

HRID 2042214 reaction equation
Br[C:2]1[C:6]2[N:7]=[C:8]([NH2:11])[N:9]=[CH:10][C:5]=2[S:4][CH:3]=1.[NH2:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][CH:18]=1>>[NH2:12][C:13]1[CH:18]=[C:17]([C:2]2[C:6]3[N:7]=[C:8]([NH2:11])[N:9]=[CH:10][C:5]=3[S:4][CH:3]=2)[CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 922693-Aminophenylboronic acidHCID 671201377-Bromothieno[3,2-d]pyrimidin-2-amine

Product 1

HCID 671201477-(3-Aminophenyl)thieno[3,2-d]pyrimidin-2-amineYield 75.9%

Procedure

7-(3-Aminophenyl)thieno[3,2-d]pyrimidin-2-amine (160 mg, 75% yield) was prepared in the same manner as Step 6 of Example 1 using 7-bromothieno[3,2-d]pyrimidin-2-amine (200 mg, 0.87 mmol) and 3-aminophenylboronic acid (120 mg, 0.87 mmol).

Sources & evidence

ORD record
ord-4df119f26d5d495a87038448896fd805
Source dataset
uspto-grants-2013_11
Patent number
US08586580B2

Reaction notes

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