Potassium Carbonate → HCID 67120138, compound

Participants

Reaction Conditions

Reaction Steps

4-(2-(6-Morpholinopyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)benzylmethanesulfonate (30 mg, 0.06 mmol) was dissolved in N,N-dimethylformamide (1 mL) and potassium carbonate (17 mg, 0.12 mmol) and 1-ethylpiperazine (38 μL, 0.30 mmol) were added. The reaction mixture was stirred at 80° C. for a day, diluted with ethyl acetate, and washed with brine. The organic layer was dried with magnesium sulfate, filtered with celite, and then concentrated. Purification by chromatography (5% methanol/dichloromethane) yielded the target compound (22 mg, 70% yield).

Provenance & Evidence