HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-Ethylpiperazin-1-yl)pyridin-3-amine → N-Cyclopropyl-3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-Ethylpiperazin-1-yl)pyridin-3-amine | HCID 9161674 | — |
| Reactant | 3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)-N-cyclopropylbenzamide | HCID 86673220 | — |
| Product | N-Cyclopropyl-3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)benzamide | HCID 52931892 | 51.1% |
Reaction Steps
N-Cyclopropyl-3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)benzamide (23 mg, 50% yield) was prepared in the same manner as Step 10 of Example 1 using 3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)-N-cyclopropylbenzamide (30 mg, 0.09 mmol) and 6-(4-ethylpiperazin-1-yl)pyridin-3-amine (28 mg, 0.14 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586580B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-fd8c51339903413197a70611545c50be |
| Source note | uspto-grants-2013_11 |