Quinoline-3-boronic acid → HCID 86673221, compound

HRID 2042227Notes

Reaction equation

HRID 2042227 reaction equation
Br[C:2]1[C:6]2[N:7]=[C:8]([Cl:11])[N:9]=[CH:10][C:5]=2[S:4][CH:3]=1.[N:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[C:14](B(O)O)[CH:13]=1>>[Cl:11][C:8]1[N:9]=[CH:10][C:5]2[S:4][CH:3]=[C:2]([C:14]3[CH:13]=[N:12][C:21]4[C:16]([CH:15]=3)=[CH:17][CH:18]=[CH:19][CH:20]=4)[C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 2734663Quinoline-3-boronic acidHCID 569657247-Bromo-2-chlorothieno(3,2-d)pyrimidine

Product 1

HCID 86673221HCID 86673221, compoundYield 58%

Procedure

2-Chloro-7-(quinolin-3-yl)thieno[3,2-d]pyrimidine (140 mg, 58% yield) was prepared in the same manner as Step 6 of Example 1 using 7-bromo-2-chlorothieno[3,2-d]pyrimidine (200 mg, 0.81 mmol) and quinolin-3-ylboronic acid (140 mg, 0.81 mmol).

Sources & evidence

ORD record
ord-4369682cf7d84a66afad34aa0912a8a0
Source dataset
uspto-grants-2013_11
Patent number
US08586580B2

Reaction notes

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