6-(4-Ethylpiperazin-1-yl)pyridin-3-amine → HCID 52931947, compound

HRID 2042228Notes

Reaction equation

HRID 2042228 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[S:10][CH:9]=[C:8]([C:11]3[CH:12]=[N:13][C:14]4[C:19]([CH:20]=3)=[CH:18][CH:17]=[CH:16][CH:15]=4)[C:6]=2[N:7]=1.[CH2:21]([N:23]1[CH2:28][CH2:27][N:26]([C:29]2[N:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=2)[CH2:25][CH2:24]1)[CH3:22]>>[CH2:21]([N:23]1[CH2:24][CH2:25][N:26]([C:29]2[N:34]=[CH:33][C:32]([NH:35][C:2]3[N:3]=[CH:4][C:5]4[S:10][CH:9]=[C:8]([C:11]5[CH:12]=[N:13][C:14]6[C:19]([CH:20]=5)=[CH:18][CH:17]=[CH:16][CH:15]=6)[C:6]=4[N:7]=3)=[CH:31][CH:30]=2)[CH2:27][CH2:28]1)[CH3:22]

Participants

3

Reactant 2

HCID 91616746-(4-Ethylpiperazin-1-yl)pyridin-3-amineHCID 86673221HCID 86673221, compound

Product 1

HCID 52931947HCID 52931947, compoundYield 68.4%

Procedure

N-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)-7-(quinolin-3-yl)thieno[3,2-d]pyrimidin-2-amine (32 mg, 67% yield) was prepared in the same manner as Step 10 of Example 1 using 2-chloro-7-(quinolin-3-yl)thieno[3,2-d]pyrimidine (30 mg, 0.10 mmol) and 6-(4-ethylpiperazin-1-yl)pyridin-3-amine (31 mg, 0.15 mmol).

Sources & evidence

ORD record
ord-67e95f2cafe9446fb316f35b8b3bbf02
Source dataset
uspto-grants-2013_11
Patent number
US08586580B2

Reaction notes

Loading…