3-Nitrophenylboronic Acid → HCID 58408013, compound

HRID 2042229Notes

Reaction equation

HRID 2042229 reaction equation
Br[C:2]1[C:6]2[N:7]=[C:8]([Cl:11])[N:9]=[CH:10][C:5]=2[S:4][CH:3]=1.[N+:12]([C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1)([O-:14])=[O:13]>>[Cl:11][C:8]1[N:9]=[CH:10][C:5]2[S:4][CH:3]=[C:2]([C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([N+:12]([O-:14])=[O:13])[CH:20]=3)[C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 16773-Nitrophenylboronic AcidHCID 569657247-Bromo-2-chlorothieno(3,2-d)pyrimidine

Product 1

HCID 58408013HCID 58408013, compoundYield 73%

Procedure

2-Chloro-7-(3-nitrophenyl)thieno[3,2-d]pyrimidine (430 mg, 73% yield) was prepared in the same manner as Step 6 of Example 1 using 7-bromo-2-chlorothieno[3,2-d]pyrimidine (500 mg, 2.02 mmol) and 3-nitrophenylboronic acid (337 mg, 2.02 mmol).

Sources & evidence

ORD record
ord-ec56453cfc4b4b9b838ab73bb794bce0
Source dataset
uspto-grants-2013_11
Patent number
US08586580B2

Reaction notes

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