6-(Morpholino)pyridin-3-amine → HCID 67120130, compound

HRID 2042230Notes

Reaction equation

HRID 2042230 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[S:10][CH:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=3)[C:6]=2[N:7]=1.[O:20]1[CH2:25][CH2:24][N:23]([C:26]2[N:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=2)[CH2:22][CH2:21]1>>[O:20]1[CH2:25][CH2:24][N:23]([C:26]2[N:31]=[CH:30][C:29]([NH:32][C:2]3[N:3]=[CH:4][C:5]4[S:10][CH:9]=[C:8]([C:11]5[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=5)[C:6]=4[N:7]=3)=[CH:28][CH:27]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 1040596-(Morpholino)pyridin-3-amineHCID 58408013HCID 58408013, compound

Product 1

HCID 67120130HCID 67120130, compoundYield 80.6%

Procedure

N-(6-Morpholinopyridin-3-yl)-7-(3-nitrophenyl)thieno[3,2-d]pyrimidin-2-amine (480 mg, 78% yield) was prepared in the same manner as Step 10 of Example 1 using 2-chloro-7-(3-nitrophenyl)thieno[3,2-d]pyrimidine (400 mg, 1.37 mmol) and 6-morpholinopyridin-3-amine (369 mg, 2.06 mmol).

Sources & evidence

ORD record
ord-7af36f100d764a2db6aecbbf295987f6
Source dataset
uspto-grants-2013_11
Patent number
US08586580B2

Reaction notes

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