Stannous chloride dihydrate → HCID 52932180, compound

Participants

Reaction Conditions

Reaction Steps

N-(6-Morpholinopyridin-3-yl)-7-(3-nitro phenyl)thieno[3,2-d]pyrimidin-2-amine (476 mg, 1.10 mmol) was dissolved in ethanol (3.5 mL) and tin(II) chloride dihydrate (1238 mg, 5.48 mmol) was added. The reaction mixture was stirred at 80° C. for 2 hours. After removing ethanol by distillation under reduced pressure, ammonia water was slowly added to make pH 5. Sodium carbonate was added to thus prepared yellow precipitate until the pH reached 7. The precipitate was filtered and washed several times with ethyl acetate. The filtrate was concentrated and the resultant target compound (338 mg, 76%) was used without purification.

Provenance & Evidence