HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-Ethylpiperazin-1-yl)pyridin-3-amine → N-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-Ethylpiperazin-1-yl)pyridin-3-amine | HCID 9161674 | — |
| Reactant | 2-Chloro-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidine | HCID 86673222 | — |
| Product | N-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-2-amine | HCID 52932073 | 61.3% |
Reaction Steps
N-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-2-amine (19 mg, 61% yield) was prepared in the same manner as Step 10 of Example 1 using 2-chloro-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidine (20 mg, 0.64 mmol) and 6-(4-ethylpiperazin-1-yl)pyridin-3-amine (13 mg, 0.064 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586580B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-15a65c23e49e4ae9bc740dac949e9bb5 |
| Source note | uspto-grants-2013_11 |