HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Morpholino)pyridin-3-amine → N7-Methyl-N2-(6-morpholinopyridin-3-yl)-N7-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-2,7-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Morpholino)pyridin-3-amine | HCID 104059 | — |
| Reactant | 2-chloro-N-methyl-N-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-7-amine | HCID 86673225 | — |
| Product | N7-Methyl-N2-(6-morpholinopyridin-3-yl)-N7-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-2,7-diamine | HCID 52932124 | 76.7% |
Reaction Steps
N7-Methyl-N2-(6-morpholinopyridin-3-yl)-N7-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-2,7-diamine (16 mg, 76% yield) was prepared in the same manner as Step of Example 1 using 2-chloro-N-methyl-N-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-7-amine (15 mg, 0.041 mmol) and 6-morpholinopyridin-3-amine (9 mg, 0.049 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586580B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-2f31b18d69a646ac9fcf17ecb7cc074b |
| Source note | uspto-grants-2013_11 |