Hydrochloric Acid → N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride

HRID 2042241Notes

Reaction equation

HRID 2042241 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[N:14]=[CH:13][C:12]([NH:15][C:16]3[N:17]=[CH:18][C:19]4[S:24][CH:23]=[C:22]([C:25]5[CH:26]=[C:27]([NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH:28]=[CH:29][CH:30]=5)[C:20]=4[N:21]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[ClH:36]>O1CCCC1.O1CCOCC1>[ClH:36].[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[N:14]=[CH:13][C:12]([NH:15][C:16]3[N:17]=[CH:18][C:19]4[S:24][CH:23]=[C:22]([C:25]5[CH:26]=[C:27]([NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH:28]=[CH:29][CH:30]=5)[C:20]=4[N:21]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 51347359N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Product 1

HCID 52932127N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide (300 mg, 0.589 mmol) was dissolved in tetrahydrofuran (5 mL) and then 4 M hydrogen chloride (147 μL) dissolved in dioxane was added at room temperature. 30 minutes later, thus prepared precipitate was filtered and dried at room temperature. The target compound N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride (305 mg) was yielded.

Workup

  1. additionwas added at room temperature
  2. filtration30 minutes later, thus prepared precipitate was filtered
  3. customdried at room temperature

Sources & evidence

ORD record
ord-2a4a0428de054373bcbeb2390b50480c
Source dataset
uspto-grants-2013_11
Patent number
US08586580B2

Reaction notes

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