HCID 178478592, compound → HCID 178520749, compound

HRID 2042412Notes

Reaction equation

HRID 2042412 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH:6]=[CH:5]1.C[O:29][C:30](=O)[CH2:31][C@H:32]1[CH2:37][CH2:36][C@H:35]([OH:38])[CH2:34][CH2:33]1>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:30](=[O:29])[CH2:31][C@H:32]5[CH2:37][CH2:36][C@H:35]([OH:38])[CH2:34][CH2:33]5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH:6]=[CH:5]1

Participants

3

Reactant 2

HCID 178478592HCID 178478592, compound2×HCID 178500705HCID 178500705, compound

Product 1

HCID 178520749HCID 178520749, compound

Procedure

The title compound, white solid (159 mg, quant.), MS (ISP) m/z=469.3 [(M+H)+], was prepared in analogy to example 2 from trans-4-[2-(4-furo[3,2-c]pyridin-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride (intermediate A) (150 mg, 0.34 mmol) and trans-(4-hydroxy-cyclohexyl)-acetic acid methyl ester [CAS-Nr. 1124174-16-8, WO 2010/031735] (71 mg, 0.41 mmol). The purification was performed by precipitation from Et2O.

Sources & evidence

ORD record
ord-6fc2f068dfd04f20bc91207de83cb8ba
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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