3-Methoxypropionic acid → HCID 178495586, compound

Participants

Reaction Steps

The title compound was prepared in analogy to example 4 starting from trans-4-[2-(4-thieno[3,2-c]pyridin-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride (intermediate B) (100 mg, 0.22 mmol) and 3-methoxypropionic acid (24 mg, 0.23 mmol). Purification by flash chromatography on silica gel (CH2Cl2/MeOH 95:5). White crystals (61 mg, 64%), MS (ISP) m/z=431.3 [(M+H)+].

Provenance & Evidence