Oxane-4-carboxylic acid → HCID 178523712, 화합물

HRID 2042430노트

반응식

HRID 2042430 반응식
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[O:28]1[CH2:33][CH2:32][CH:31]([C:34](O)=[O:35])[CH2:30][CH2:29]1>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:34]([CH:31]5[CH2:32][CH2:33][O:28][CH2:29][CH2:30]5)=[O:35])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1

참가 물질

3

반응물 2

HCID 219302Oxane-4-carboxylic acidHCID 178478589HCID 178478589, 화합물2회

생성물 1

HCID 178523712HCID 178523712, 화합물

실험 절차

The title compound, off-white solid (101 mg, 91%), MS (ISP) m/z=443.5 [(M+H)+], mp 263° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and tetrahydropyran-4-yl-carboxylic acid.

출처 및 근거

ORD 기록
ord-2eff2236e8224a7297c6b25916d7cd76
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586579B2

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