2-(1,4-Dioxan-2-yl)acetic acid → HCID 178520373, 화합물

HRID 2042434노트

반응식

HRID 2042434 반응식
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[O:28]1[CH2:33][CH2:32][O:31][CH2:30][CH:29]1[CH2:34][C:35](O)=[O:36]>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:35](=[O:36])[CH2:34][CH:29]5[CH2:30][O:31][CH2:32][CH2:33][O:28]5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1

참가 물질

3

반응물 2

HCID 184692262-(1,4-Dioxan-2-yl)acetic acidHCID 178478589HCID 178478589, 화합물2회

생성물 1

HCID 178520373HCID 178520373, 화합물

실험 절차

The title compound, white solid (107 mg, 78%), MS (ISP) m/z=459.4 [(M+H)+], mp 186° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (132 mg, 0.3 mmol) and rac-(1,4-dioxan-2-yl)-acetic acid.

출처 및 근거

ORD 기록
ord-664ac6f795254e6e8c94674f71f29fb8
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586579B2

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