(R)-Tetrahydro-3-furoic acid → HCID 178523711, compound

Participants

Reaction Steps

The title compound, white solid (101 mg, 79%), MS (ISP) m/z=429.3 [(M+H)+], mp 208.5° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-Dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (132 mg, 0.3 mmol) and rac-tetrahydrofuran-3-carboxylic acid.

Provenance & Evidence