4-(Trifluoromethyl)benzoic acid → HCID 178523698, compound

Participants

Reaction Steps

The title compound, off-white solid (111 mg, 88%), MS (ISP) m/z=503.3 [(M+H)+], mp 227° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and 4-trifluoromethyl-benzoic acid.

Provenance & Evidence