Oxane-3-carboxylic acid → HCID 178523709, compound

HRID 2042450Notes

Reaction equation

HRID 2042450 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[O:28]1[CH2:33][CH2:32][CH2:31][CH:30]([C:34](O)=[O:35])[CH2:29]1>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:34]([CH:30]5[CH2:31][CH2:32][CH2:33][O:28][CH2:29]5)=[O:35])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 16767361Oxane-3-carboxylic acidHCID 178478589HCID 178478589, compound2×

Product 1

HCID 178523709HCID 178523709, compound

Procedure

The title compound, white solid (91 mg, 82%), MS (ISP) m/z=443.5 [(M+H)+], mp 216° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and rac-tetrahydro-pyran-3-carboxylic acid.

Sources & evidence

ORD record
ord-a351cc89459249b697f875065ad9c115
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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