HCID 55301231, compound → HCID 178520764, compound

HRID 2042456Notes

Reaction equation

HRID 2042456 reaction equation
Cl.Cl.Cl.[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1.[O:28]1[CH2:33][CH2:32][O:31][CH2:30][C@H:29]1[CH2:34][C:35](O)=[O:36]>>[O:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:35](=[O:36])[CH2:34][C@@H:29]5[CH2:30][O:31][CH2:32][CH2:33][O:28]5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 55301231HCID 55301231, compoundHCID 178478589HCID 178478589, compound2×

Product 1

HCID 178520764HCID 178520764, compound

Procedure

The title compound, white solid (92 mg, 80%), MS (ISP) m/z=459.5 [(M+H)+], mp 193.5° C., was prepared in accordance with the general method of example 32 from trans-4-{2-[4-(2,3-dihydrofuro[3,2-c]pyridin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexanamine trihydrochloride (intermediate C) (110 mg, 0.25 mmol) and (R)-[1,4]dioxan-2-yl-acetic acid.

Sources & evidence

ORD record
ord-bf13cf1d2282442b9da8bf537a7118bd
Source dataset
uspto-grants-2013_11
Patent number
US08586579B2

Reaction notes

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